Benadryl should be stopped at least 4 weeks before the ayahuasca ceremony. This gap allows for the body to flush out the drug fully and also lessens the chances of some adverse negative interactions. As with any other medicine, changes to the regimen should be discussed with the healthcare professional.
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⚠️ Why Is This Important?
The MAO inhibitors (MAOIs) in ayahuasca can interact dangerously with numerous medications. From the ones mentioned, antihistamines and Benadryl would pose the major risk. These pose grave health risks such as:
Excessive serotonin in the body can cause Serotonin Syndrome: This can threaten life.
Hypertensive Crisis: Harsh results of sustained blood pressure
Cardiovascular Complications: irregularities in the heart beats.
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This occurs as both Benadryl and ayahuasca have an effect on brain neurotransmitter systems which results in amplified action via combination.
📋 Summary Table
Medication Recommended Discontinuation Period Before Ayahuasca Reason
Benadryl At least 4 weeks To avoid disastrous interactions with the ayahuasca’s MAOIs.
✅ Recommendations
Consult Your Doctor: Discuss halting any prescription medicine beforehand.
Tell Retreat Organizers: During the screening phase list all prescription medications and supplements you are using.
Do Not Initiate Treatment on Your Own: Without confirmatory examinations, you should not substitute Benadryl for any other over-the-counter medications.